Publications

Group highlights

(For a full list of publications see below or go to Google Scholar)

The potential of myelin-sensitive imaging: Redefining spatiotemporal patterns of myeloarchitecture

Recent advances in magnetic resonance imaging (MRI) pave the way for approximation of myelin content in-vivo. In this review, our main goal was to determine how to best capitalise on myelin-sensitive imaging.

Paquola C & Hong, SJ

BiolPsych 2022

Closing the mechanistic gap: the value of microarchitecture in understanding cognitive networks

Contemporary research linking spatial patterns of neural activity to psychological constructs describes ‘where’ hypothesised functions occur, but not ‘how’ these regions contribute to cognition. This perspective highlights emerging insights into how microarchitecture can constrain network accounts of human cognition.

Paquola C, Amunts K, Evans AC, Smallwood J, Bernhardt BC.

TICS 2022;07:001

The BigBrainWarp toolbox for integration of BigBrain 3D histology with multimodal neuroimaging

Neuroimaging stands to benefit from emerging ultrahigh-resolution 3D histological atlases of the human brain; the first of which is ‘BigBrain’. Here, we review recent methodological advances for the integration of BigBrain with multi-modal neuroimaging and introduce a toolbox, ‘BigBrainWarp’, that combines these developments. See more on the Tools page.

Paquola C, Royer J, Lewis LB, Lepage C, Glatard T, Wagstyl K, DeKraker J, Toussaint PJ, Valk SL, Collins L, Khan AR, Amunts K, Evans AC, Dickscheid T, Bernhardt BC.

eLife 2021;10:e70119

Convergence of cortical types and functional motifs in the mesiotemporal lobe

The mesiotemporal lobe (MTL) is implicated in many cognitive processes, is compromised in numerous brain disorders, and exhibits a gradual cytoarchitectural transition from six-layered parahippocampal isocortex to three-layered hippocampal allocortex. Leveraging an ultra-high-resolution histological reconstruction of a human brain, our study showed that the dominant axis of MTL cytoarchitectural differentiation follows the iso-to-allocortical transition and depth-specific variations in neuronal density. Our findings establish that the combination of micro- and macrostructural features allow the MTL to represent dominant motifs of whole-brain functional organisation.

Paquola C, Benkarim O, DeKraker J, Larivière S, Frässle S, Royer J, Tavakol S, Valk S, Bernasconi A, Bernasconi N, Khan A, Evans A, Razi A, Smallwood J & Bernhardt BC

eLife 2020;9:e60673

A multi-scale cortical wiring space links cellular architecture, functional dynamics and hierarchies in humans

The vast net of fibres within and underneath the cortex is optimised to support the convergence of different levels of brain organisation. Here, we propose a novel coordinate system of the human cortex based on an advanced model of its connectivity. Our approach is inspired by seminal, but so far largely neglected models of cortico–cortical wiring established by postmortem anatomical studies and capitalises on cutting-edge in vivo neuroimaging and machine learning. Our results advance our understanding of how cell-specific neurobiological gradients produce a hierarchical cortical wiring scheme that is concordant with increasing functional sophistication of human brain organisation.

Paquola C, Seidlitz J, Benkarim O, Royer J, Klimes P, Bethlehem RAI, Larivière S, Vos De Wael R, Hall J, Frauscher B, Smallwood J & Bernhardt BC

PLoS Biol 18(11):e3000979

Shifts in myeloarchitecture characterise adolescent development of cortical gradients

Depth-dependent trajectories of intracortical myeloarchitectural development contribute to the maturation of structural hierarchies in the human neocortex, providing a model for adolescent development that bridges microstructural and macroscopic scales of brain organisation

Paquola C, Bethlehem RAI, Seidlitz J, Wagstyl K, Romero-Garcia R, Whitaker KJ, Vos De Wael R, Williams GB, NSPN Consortium, Vértes PE, Margulies DS, Bernhardt BC & Bullmore, ET

eLife 2019;8:e50482

Microstructural and functional gradients are increasingly dissociated in transmodal cortices

We developed a novel approach to model the similarity of microstructural profiles sampled in the direction of cortical columns. Our approach was initially formulated based on an ultra-high–resolution 3D histological reconstruction of an entire human brain and then translated to myelin-sensitive magnetic resonance imaging (MRI) data in a large cohort of healthy adults. This novel method identified a system-level gradient of microstructural differentiation traversing from primary sensory to limbic regions that followed shifts in laminar differentiation and cytoarchitectural complexity.

Paquola C, Vos De Wael R, Wagstyl K, Bethlehem R, Hong SJ, Seidlitz J, Evans AC, Mišić B, Bullmore E, Margulies DS, Smallwood J & Bernhardt BC

PLoS Biol 17(5):e3000284

 

Full List

The potential of myelin-sensitive imaging: Redefining spatiotemporal patterns of myeloarchitecture
Paquola C & Hong, SJ
BiolPsych 2022

Closing the mechanistic gap: the value of microarchitecture in understanding cognitive networks
Paquola C, Amunts K, Evans AC, Smallwood J, Bernhardt BC.
TICS 2022;07:001

The BigBrainWarp toolbox for integration of BigBrain 3D histology with multimodal neuroimaging
Paquola C, Royer J, Lewis LB, Lepage C, Glatard T, Wagstyl K, DeKraker J, Toussaint PJ, Valk SL, Collins L, Khan AR, Amunts K, Evans AC, Dickscheid T, Bernhardt BC.
eLife 2021;10:e70119

Convergence of cortical types and functional motifs in the mesiotemporal lobe
Paquola C, Benkarim O, DeKraker J, Larivière S, Frässle S, Royer J, Tavakol S, Valk S, Bernasconi A, Bernasconi N, Khan A, Evans A, Razi A, Smallwood J & Bernhardt BC
eLife 2020;9:e60673

A multi-scale cortical wiring space links cellular architecture, functional dynamics and hierarchies in humans
Paquola C, Seidlitz J, Benkarim O, Royer J, Klimes P, Bethlehem RAI, Larivière S, Vos De Wael R, Hall J, Frauscher B, Smallwood J & Bernhardt BC
PLoS Biol 18(11):e3000979

Dispersion of functional gradient across the lifespan
Bethlehem RAI, Paquola C, Seidlitz J, Ronan L, Bernhardt BC, Cam-CAN Consortium & Tsvetanov K

Myeloarchitecture gradients in the human insula: Histological underpinnings and association to intrinsic functional connectivity
Royer J, Paquola C, Larivière S, Vos de Wael R, Tavakol S, Lowe A, Benkarim O, Evans AC, Bzdok D, Smallwood J, Frauscher B & Bernhardt BC

Shifts in myeloarchitecture characterise adolescent development of cortical gradients
Paquola C, Bethlehem RAI, Seidlitz J, Wagstyl K, Romero-Garcia R, Whitaker KJ, Vos De Wael R, Williams GB, NSPN Consortium, Vértes PE, Margulies DS, Bernhardt BC & Bullmore, ET
eLife 2019;8:e50482

Targeting Age-Related Difference in Brain and Cognition with Multimodal Imaging and Connectome Topography Profiling
Lowe A, Paquola C, Vos de Wael R, Girn M, Larivière S, Tavakol S, Caldairou B, Royer J, Schrader D, Bernasconi A, Bernasconi N, Spreng N & Bernhardt BC

Microstructural and functional gradients are increasingly dissociated in transmodal cortices
Paquola C, Vos De Wael R, Wagstyl K, Bethlehem R, Hong SJ, Seidlitz J, Evans AC, Mišić B, Bullmore E, Margulies DS, Smallwood J & Bernhardt BC
PLoS Biol 17(5):e3000284